Ready to change your life?Start Now! Contact Us

Exploring The Relationship Between Exercise and Immunity

November 30, 2020

By Sadie Engelken, Duke Diet & Fitness Intern from Carroll University, and the Duke Lifestyle and Weight Management Center Nutrition Team.

The immune system is the body’s protection system. The body recognizes and defends against bacteria, viruses, and foreign and/or harmful substances to prevent or limit infection or disease. Regular exercise is an effective way to keep the immune system strong; however, there is a lot of conflicting information about keeping your immune system in shape.

We outline five key points to consider when strengthening the immune system through regular exercise.

Interval training can be an effective way to strengthen the immune system.

Research about the effects of regular exercise on the immune system is still ongoing.

Previous research stated that acute bouts of vigorous and/or prolonged exercise resulted in detrimental effects on the immune system, including an increased risk of infection and decreased blood immune cells, and an increased likelihood of becoming sick the following days.3 The opposite has now been supported. Current research shows that after an acute bout of aerobic activity, there is a redistribution of immunity cell components resulting in improved surveillance, coordination, and regulation of the immune system. These results, therefore, support that high-intensity exercise; especially in the form of interval training, can be an effective way to strengthen the immune system. 2, 6

Physical exercise can strengthen your immune system.

Increased circulation results in more mobilization of immune cells, removal of damaged cells, decreased inflammation, and enhanced bodily functions. The most beneficial impact occurs when exercise comprises a lasting, maintained aerobic and resistance training routine. The impact of these benefits increases over time; each mode of training improves the immune system differently. Aerobic training works on the immune cells themselves by increasing their numbers and activity. Resistance training improves inflammatory status and removal of diseased or mutated tissues. Research has shown these benefits can be seen in as little as one month, and even if training were to be discontinued, the benefits would remain even after two months. 1, 2, 4, 6

When can exercise weaken the immune system?

It is important to note there is a point at which exercise can weaken the immune system. With long-term intensive or excessive training, multiple parts of the system can weaken, resulting in decreased function and increased risk of infection. This occurs when the duration of a single exercise session is too long, the intensity is too high, or when a person does not allow the body time to recover.1, 2, 5

Key takeaways

  • Brief bouts of vigorous activity will improve the immune system.
  • A routine of both aerobic and resistance activities will give the best boost to your immunity.
  • Overtraining can result from long-term, intensive, excessive training resulting in declined function and increased risk of infection.
  • It is important to check in with your emotions, performance, and body to make sure you are not overtraining.
  • Most importantly, keep moving because any activity will immediately benefit the immune system.


1. Au, K. (2017, November 6). Should you exercise when sick?

2. Calabrese, L. (2017, July 28). How to Train and Maintain Your Immune System.

3. Campbell, John P., and James E. Turner. Debunking the Myth of Exercise-Induced Immune Suppression: Redefining the Impact of Exercise on Immunological Health Across the Lifespan.

4. Harvard Health Publishing. (2018, July 16). How to boost your immune system.

5. MacKinnon, L. T. (2000), Overtraining effects on immunity and performance in athletes.

6. Sellami, Maha & Gasmi, Maha & Denham, Joshua & Hayes, Lawrence & Stratton, Dan & Padulo, Johnny & Bragazzi, Nicola. (2018). Effects of acute and chronic exercise on immunological parameters in older adults.

About the Duke Lifestyle & Weight Management Center

Medically Supervised Weight Loss

Duke weight management specialists counsel and oversee non-surgical treatments to help you change your eating habits, adopt healthy lifestyle habits, lose weight, and maintain weight loss. We have been helping people successfully lose weight, manage medical conditions, and transform their lives for over 50 years. Here’s how we can help you live a healthy, active, fulfilling life.

Make An Appointment Today



Cultivate a Sense of Awe: 6 Ideas to Experience Wonder

Experiencing awe has been proven to impact our emotional well-being significantly. These moments can transform our perspective and enrich our lives while providing mental and physical benefits. In this article, we will explore the key benefits of awe and provide five practical ideas to help you cultivate a sense of ...


6 Tips to Sit Less and Move More

Living a sedentary lifestyle can have a significant impact on your health. Inactivity is associated with various health risks, such as obesity, diabetes, and heart disease. The good news is that incorporating movement into your day can help combat these issues. Here are six tips to help you sit less ...


10 Tips to Detect Nutrition Misinformation Online

Carolyn Kleffman, MS. Nutrition Intern at Duke Lifestyle & Weight Management Center. Christine B. Tenekjian, MPH, RDN at Duke Lifestyle & Weight Management Center. Protecting ourselves from nutrition misinformation online can be difficult. Testimonials and paid content creators can be very convincing and push products on consumers. Below, ...


For more information about

Duke Integrative Medicine and our various services and programs, please join our mailing list.

error: Content is protected !!